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The United States Government Manual
The Nation's district courts are the trial courts of general Federal jurisdiction. These courts resolve disputes by determining the facts and applying legal principles to decide which party is right. Each State has at least one district court, and large States have as many as four. There are 89 district courts in the 50 States, plus one in the District of Columbia and another in the Commonwealth of Puerto Rico. Three other U.S. Territories also have courts that hear Federal cases: Guam and the Northern Mariana and Virgin Islands.
At present, each district court has from 2 to 28 Federal district judgeships, depending upon the amount of judicial work within its territory. Only one judge is usually required to hear and decide a case in a district court, but in some limited cases it is required that three judges be called together to comprise the court (28 U.S.C. 2284). The judge senior in commission who is under 70 years of age (65 at inception of term), has been in office for at least 1 year, and has not previously been chief judge, serves as chief judge for a 7-year term. There are 645 permanent district judgeships in the 50 States and 15 in the District of Columbia. There are seven district judgeships in Puerto Rico. District judges hold their offices during good behavior as provided by Article III, section 1, of the Constitution. However, Congress may temporary judgeships for a court with the provision that when a future vacancy occurs in that district, such vacancy shall not be filled. Each district court has one or more United States magistrate judges and bankruptcy judges, a clerk, a United States attorney, a United States marshal, probation officers, court reporters, and their staffs. The jurisdiction of the district courts is set forth in title 28, chapter 85, of the United States Code and at 18 U.S.C. 3231.
Cases from the district courts are reviewable on appeal by the applicable court of appeals.http://www.uscourts.gov/about-federal-courts/court-role-and-structure